Some very nice posts.
I tend to agree with the 'pro posts' that 3D games are entirely plausible and acheivable.
The majority of the ideas and views offered by those that think it impractical seem fixed on a 'cubic' representation of the Galciv Universe. (That is to say, several layers of 2D to simulate a 3D version of todays interface.)
This would not seem logical for a 3D representation.
Rather than having to micro-manage every possible move/location, you could simply select a destination (Star) within a 3D Galaxy.
This may seem a little restrictive, in terms of application to GalCiv in that space, would becomes only a means to travel from destination A, to destination B. But, would this be such a bad idea?
Imagine the following....
Examining the 3D 'Galaxy map' a player spots a Drengin Fleet heading towards the Mizar system. After zooming in/rotating, the player is not sure but the Drengin fleet has only just entered scanner range and is just 7 weeks away. There is another possible destination for the fleet as the Casper system is only 5 parsecs from Mizar in the same general direction, and it is currently unoccupied.
To be safe, the player looks around and sees one of their own fleets in the vicinity.
(This fleet will almost certainly contain the 'Starship Enterprise' [TM] as that ship is the only one that is ever in the vicinity of anything that ever happens, the nearest help will inevitably be several weeks away, or, undergoing a refit in the nearest starbase.)
Computer: 'Fleet 105, en-route to Rigel system, ETA 11 weeks.'
Player: 'Calculate eta to Mizar'
Computer: 'ETA at Mizar from current fleet location 6 weeks'
So, do you divert the fleet or not?
Do you wait 1 more week to verify that the fleet is going to Casper?(Fleet 105 will have moved out of range to intercept in 1 more week)
Whatever you decide to do, there is no need to clik on anything for movement in the Galaxy view except the destination system for the fleet. i.e to divert it to Mizar, or let it continue to Rigel.
The point here, is that all the tactical stuff, will take place at Mizar, and not in deep space. Nor is there any need for it to take place in deep space if you think about it. What takes place in the Galaxy is now purely Grand Strategy.
Now, if the Grand Strategic 3D representation was of systems within the Galaxy, all that would need to be represented in the user interface at the Strategic level would be a single Star system.
Imagine the possibilities now... Thousands upon thousands of possible systems in a true 3D Galaxy.
The Star system (Strategic map) could be represented as a 3x3x3 cubic display giving 27 possible sectors each of which could conatin a feature, or not.
Once at the system, all you would need to do is select a sector as the destination.
Finally, at the 'Tactical level' all that needs to be represented is a single sector, with any feature contained in it.
It would also save on memory, as you only need to ever view
a) the Galaxy, beautifully rendered in true 3D or,

A single star system.
c) A sector within a star system
I know this needs a lot more thought, but, well... it's a start.
What do you think?