Demiansky

Should we Clone a Neanderthal?

Should we Clone a Neanderthal?

The title says it all.  As of now, we actually have the technological advancements to do it, as well as a fully sequenced Neanderthal Genome (at the moment, a few minor techniques are in the works that would make it easier).  So if we could clone a Neanderthal without error, would you be okay with it?  Why or why not? 

520,873 views 166 replies
Reply #76 Top

Quoting caross73, reply 73
"Fire doesn't/can't do that."

 

The original life killed itself off by creating oxygen as a waste product. I'm not sure I would say that those primordial organisms weren't alive.

 

Stromatolites are thought to have produce most/all of the oxygen we use today, and they are still around in Shark Bay, Australia. However, I'm over this discussion. Were arguing over the definition of purpose and the philosophy around it and it's really not that important.

Reply #77 Top

Quoting Myles, reply 76

Quoting caross73, reply 73"Fire doesn't/can't do that."

 

The original life killed itself off by creating oxygen as a waste product. I'm not sure I would say that those primordial organisms weren't alive.

 
Stromatolites are thought to have produce most/all off the oxygen we use today, and they are still around in Shark Bay, Australia. However, I'm over this discussion. Were arguing over the definition of purpose and the philosophy around it and it's really not that important.

 

All true, but the original life was (best guess) anaerobic, and its descendents can only be found around hot springs and thermal vents. Oxygen kills them in the laboratory, even though they make it. Oxygen utilizing organisms arose later after these guys pretty much relegated themselves to the most hostile places on the planet (to us).

 

As for the definition of purpose, I think its sort of important. Otherwise you start thinking that there is all some destiny and that we MUST breed ourselves into extinction because breeding is our purpose. The only people we need to satisfy are ourselves, there isn't some external hall monitor telling us where to go and what to do - "why we are here" , so what we choose as our purpose is really important.

Reply #79 Top

Quoting caross73, reply 77


As for the definition of purpose, I think its sort of important. Otherwise you start thinking that there is all some destiny and that we MUST breed ourselves into extinction because breeding is our purpose. The only people we need to satisfy is ourselves, there isn't some external hall monitor telling us where to go and what to do, so what we choose as our purpose is really important.

It's a semantics argument. There is no general purpose to life, or really anything for that matter. It all just is. But if you look at things in smaller pieces, you realize they do serve a purpose now, even if they weren't 'created' in that vision.

Reply #80 Top

Quoting scharchuk, reply 78
We're too genetically different to interbreed with them, Servius.

Science says otherwise. Recent studies have found that 1-4% of DNA from certain groups of humans are from Neanderthals.  Source

 

EDIT: Interesting note, scientists believe some of the major differences in DNA between us and Neanderthals is in the bone structure and cognitive areas. So that could mean despite brains that appear similar, and even a bit larger in terms of brain mass/body mass, they may think very differently from us and could never understand the world like we do.

Reply #82 Top

That could be what we shared with our common ancestor. You do know that we share DNA with bananas as well?

Reply #84 Top

Quoting scharchuk, reply 82
That could be what we shared with our common ancestor. You do know that we share DNA with bananas as well?

LOL, we share more like 50% of our DNA with Bananas. They found specific genes that we share with them and not with every other animal.

EDIT: When I said them, I was referring to Neanderthals. Sorry for the wrong pronoun usage.

Reply #85 Top

Yeah, but its not the SAME 50%  :annoyed:

some of us are much more bananish than others.

 

Finding a bit of homology between genes absolutely essential for all terrestrial life is nothing surprising, forgetting that at a certain point between any two stretches of DNA there HAS to be measurable similarity. There are only 4 letters. You try creating two strings, one million base pairs long, and see how hard you have to work so that only half the letters the same.

 

Edit: Specific genes shared with plants but not other mammals? You DON'T SAY. This I need to read about.

 

 

Reply #86 Top

Quoting IROKONESS, reply 49
OK, no waiting. Just say No. 

There would be no situation to perceive if we didn't create them....And what a damn waste of perfectly good man-made tax money!!!

We don't need it anywhere else anyways.

I wouldn't bring back a Neanderthal for the sake of just doing it.  Having a Neanderthal to study could help us cure psychological or infectious diseases.

Reply #87 Top

Quoting caross73, reply 85
Yeah, but its not the SAME 50% 

some of us are much more bananish than others.

 

(Finding a bit of homology between genes absolutely essential for all terrestrial life is nothing surprising) And at a certain point between any two stretches of DNA there HAS to be measurable similarity. There is only 4 letters.

 

 

True, and the fact is a lot of our genes don't actually do anything(arent code for any proteins) and are just along for the ride. It was even suspected that it was other primitive 'life' trying to get an edge up and find an easy way to be 'reproduced'. However, recently it's been found that these non-coding regions actually seem to regulate other coding sequences. These 'dead' regions could also be very useful for acting as a buffer to harmful mutations, as mutations in coding regions are almost always bad and rarely result in good mutations that evolution is known for.

Reply #88 Top

I'm now extremely curious as to what is in that 50%. I'm betting transposons and repeat sequences make up the bulk of it, but thats without going on medline and finding the reference. When somebody says there is similarity, I go OF COURSE there is similarity. Its been recently shown by statistical inference that all extant life began as one lineage (as opposed to multiple origins and interbreeding), so go back far enough and everything living is directly related. But if it really is specific things, I'd like to know why THEY were conserved and not other things, and why they were specifically conserved in this branch of the animals.

 

Reply #89 Top

Weren't bananas the evidence of the existence of God because of their design?XD Or does that go in the same section as with earthquakes being caused because of loose women and wild sex?

Reply #90 Top

Quoting Wintersong, reply 89
Weren't bananas the evidence of the existence of God because of their design? Or does that go in the same section as with earthquakes being caused because of loose women and wild sex?

 

LOL. But it fits the hand!

 

Please tell me I don't have to go all evolutionary on this and explain why its hogwash... wild bananas look completely different than the selectively bred chiquita 'Cavendish' varietal which was largely invented by the indigenous people of what is now Papua / New Guinea.

Every fruit has a consumer that directed its evolution. In the case of avocados, it's an extinct sloth.

Reply #91 Top

Quoting PoSmedley, reply 18
You mean we haven't already?


Ehhh...:X

Reply #93 Top

Quoting Demiansky, reply 37
Quoting seanw3, reply 32I would be skeptical that we really have the advancements required to recreate something from its DNA. Last time I checked the methods used for cloning necessitated eggs and sperm that could then be split. My question is about the process and our ability to do so. Beyond that, nature is merely a fluid construct of humanity. Today's technology will be tomorrow's nature as our nature today is full of yesterday's technologies.

The question here isn't should we do it, but certainly how soon will we achieve it?


We definately have the technology to do it right now.  This minute.  It's just... expensive.  We wouldn't use the typical nuclear transfer method, primarily because we only have fossil DNA of Neanderthals at the moment.  We don't know how to organize them into chromosomes.  However, the idea is that you alter human DNA using Multiplex Automated Genome Engineering (MAGE) so that it resembles Neanderthal DNA.  Then, you place that DNA into a blastocyst and carry the now fertile egg to term inside of a human surrogate.  What do you get?  A neanderthal baby that is the identical twin of a Neanderthal that died 40,000 years ago (with human mitochondrial DNA.) 

The trick right now is our (MAGE) techniques, which require some improvement before we can cost effectively clone a Neanderthal. 

Also, there is really no need to "put a Neanderthal on the dissection table."  The really important stuff can be done with live cell cultures and Neuroimaging techniques that are harmless.  Basically, your Neanderthal would end up living a cloustered life on a University campus with limited automony--- kind of like a bubble boy.  After all, a Neanderthal from 40,000 years ago would have no evolved ability to resist modern viruses but would still be suceptible. 

If you are wondering how I know all this stuff, I'm writing a novel about a cloned Neanderthal called Sapiens.  I've interviewed a whole host of the leading geneticists and biological anthropologists involved in the study of recent human cousins and origins.

I like to drop the OP question wherever I go, because it's important for me to understand the general public's perception and knowledge on matters of anthropology and ethics so that I may properly depict it in my book.  Thanks for all of the responses and... continue

I was completely unaware of MAGE... it is fabulous and, added to your idea, quite original. The surrogate mother would need to do a Cesarean section, but that's not very troublesome. I also believe the success rate of this procedure would be extremely low and I'm doubtful of the capability of different species embryo of surviving for long inside the uterus of another as I'm unaware of precedents in any other animal. Still, the only major quarrel I have so far is with the quality of the DNA sequence of the Neanderthal; I think you are quite aware the human genome has a few blind spots thanks to regions of highly repeated sequences. If that's the case, I wonder how many blind spots an extinct species with low coverage and shaky sampling would have. I do not buy into the idea we have a fully workable Neanderthal genome, we have a good approximation at best.

Reply #94 Top

I think life, or existence itself, is a gift. Giving life to something, no matter the reasons, is the greatest act of kindness. Would you rather live a mostly comfortable life being pricked and prodded every day, or not exist at all? Live in a bubble, or never have a chance? Pretty simple to me, and the fact that it could potentially help millions of people, if not all of them, is simply a bonus.

Reply #95 Top

I am saddened to be reminded of the largely uselessness of our genetic makeup. Maybe we can get Stardock to budget for some DNA coding efficiency experiments. *_*

Reply #96 Top

Have you learned nothing from Jurassic Park. Nature always finds a way. The neanderthals were planning this all along.... waiting all these years for humans to bring them back to life  so they can get their revenge.

 

If that shows up as a new movie on the SciFi channel, remember you heard it here first!

Reply #97 Top

:zzz: |-O \o/ 8|  o_O *_* o_O 8| \o/ |-O :zzz:  

Reply #98 Top

its kind of useless to clone a Neandrathal because he or she would be too human-like- it wouldn't be able to live a happy life among humanity, and it would be too humanlike for us to feel good about exploiting it for our own gains.

Wow...guess you haven't met many "humans".

 

Quoting RedneckDude, reply 22
Quoting DrJBHL, reply 4There aren't enough politicians and Red Necks?  

ho hum.

Quoting WebGizmos, reply 24
Nature selected them for extinction. We should leave them be.

Next!

XD  As Phil Oaks sang, "Knock On The Door"

[With a knock on the door, knock on the door.
Here they come to take one more,
One more]

 

Science says otherwise. Recent studies have found that 1-4% of DNA from certain groups of humans are from Neanderthals.

Politicians or Red Necks?

 

 

Reply #99 Top

Quoting Sanati, reply 94
I think life, or existence itself, is a gift. Giving life to something, no matter the reasons, is the greatest act of kindness. Would you rather live a mostly comfortable life being pricked and prodded every day, or not exist at all? Live in a bubble, or never have a chance? Pretty simple to me, and the fact that it could potentially help millions of people, if not all of them, is simply a bonus.

Why do you think life is a gift? And a gift by whom?

Please, to all those pandering the word 'life' left and right, define it clearly. You can't have an argument if people keep talking in different languages.

Reply #100 Top

Quoting Finneglot, reply 99
Why do you think life is a gift? And a gift by whom?

Please, to all those pandering the word 'life' left and right, define it clearly. You can't have an argument if people keep talking in different languages.

A gift from your parents, or whoever put your cells together in a petri dish. Don't get me wrong, I'm an atheist, I meant nothing religious in my post. Why do I think it's a gift? Are you serious? You would rather not have been born? I dunno about anyone else, but I could have been born in a cage and whipped every day of my life and I'd still be glad I was alive.

 

Life: The condition that distinguishes organisms from inorganic objects and dead organisms.

I did say existence itself though, if rocks could think they should be happy their atoms and molecules came together as they did. The universe is a volatile place, the fact that anything exists at all is incredible.