Check the Manuel (he's from Barcelona) for your motherboard. I have a Gigabyte X299 Gaming 9. It has 8 slots for ram, and there is a chart in the manual showing where to put the sticks which depends on how many you have. I have 4 16GB sticks and where they are placed makes a difference.
Quad channel allows the CPU to use 4 times as much RAM at one time If you have 4 sticks (in the correct slots); that 's why you are better off having 4 8GB sticks rather than 2 16GB sticks.
Does your CPU support quad channel?