Smugglers 4. There's a demo. This game reminds me vaguely somehow of ... Puzzle Quest Galactrix ... except that all the puzzle stuff is not there, conventional combat resolution. First impression of the demo is that the ship outfitting and adventure depth is much greater. Oh, no, it's not Puzzle Quest Galactrix. This really looks pretty good, but the price is a bit steep imho, $30.
OP probably is looking for something real time rather than turn based though? Maybe cheaper wouldn't hurt? Have you looked into Freespace 2? Basic game costs about $6 at www.gog.com. It is a very old game that has been brought up to date by an enormous modding project. Prepare for a bit of tinkering to get it all working, but the steps are fully described at this link.
http://www.hard-light.net/wiki/index.php/Getting_started There is a huge and very active community playing and modding this game. There are new mission scenarios, but I do not know if being a smuggler is part of the game. Think it is mostly combat missions.
http://www.youtube.com/watch?v=8HFEmGcJcWA&feature=related freespace 2
http://www.youtube.com/watch?v=rZuA9zvxs0Q&feature=related freespace 2 custom mission
Of course, there is x3 Terran Conflict sort of the ultimate game of the very type you're looking for, but also "welcome to roasting your video card 'r us." Also welcome to a steep learning curve. Very complex.
Then too, there is Freelancer. There are some big mods for it, with really large universes. And it is an adventure game with piracy, smuggling, etc.
Eve Online, your cup of tea. Darn expensive and time consuming cup of tea.