Since patching to 1.01 the time to boot the game up has gotten extremely long.  I'm guessing 5-7 minutes after starting the program before I can load a game.  In Quickplay view you can see it slowly reeling off a list of things that it's loading.  For example:  Loading map: 72 seconds.  Loading mainscreen: 32 seconds.  Loading candidate create screen: 25 seconds.  
This is far longer than it takes to load up a highly complex game like Papyrus' NASCAR 2004 or a WW2 flight sim.